Released on = February 8, 2007, 8:32 am

Press Release Author = Debra Thai

Industry = Biotech

Press Release Summary = This week AnaSpec, one of the world's largest providers of
custom and catalog peptides, introduced fifty-five new peptides for drug discovery
research.

Press Release Body = Peptides/Amyloid Peptides
Beta-Amyloid (1-15) (Cat# 61798)
Sequence: DAEFRHDSGYEVHHQ
Sequence (3-Letter): H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-OH

Beta-Amyloid (7-22) (Cat# 61803)
This beta Amyloid 7 to 22 amino acid residues peptide was utilized in studies of the
catabolism of the b-amyloid peptides. This peptide contains several potential
iodination sites.
Sequence: DSGYEVHHQKLVFFAE
Sequence (3-Letter):
H-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-OH
Reference(s): Ghiso, J. et al. J. Biol. Chem. 279, 45897 (2004).

Biotin-LC-beta-Amyloid(1-40), mouse, rat (Cat# 61717-01)
Sequence: Biotin-LC-DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV
Sequence (3-Letter):
Biotin-LC-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Biotin-LC-beta-Amyloid(1-40), mouse, rat (Cat# 61717-05)
Sequence: Biotin-LC-DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV
Sequence (3-Letter):
Biotin-LC-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Biotin-LC-beta-Amyloid(1-40), mouse, rat (Cat# 61717-1)
Sequence: Biotin-LC-DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV
Sequence (3-Letter):
Biotin-LC-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Beta-Amyloid (1-34) (Cat# 61799)
Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGL
Sequence (3-Letter):
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-OH

Peptides/Bacterial Peptides
P69 (522-534), M. leprae (Cat# 61688)
A Mycobacteria leprae heat shock protein (M. leprae HSP65)-specific epitope. This
peptide is recognized by M. leprae HSP65-reactive CD4+ T-cell clones.
Sequence: PEKTAAPASDPTG
Sequence (3-Letter): H-Pro-Glu-Lys-Thr-Ala-Ala-Pro-Ala-Ser-Asp-Pro-Thr-Gly-OH
Reference(s): Mustafa, A. et al. Infect. Immun. 67, 5683 (1999).

Peptides/Ghrelin Peptides
Biotin-Ghrelin, bovine (Cat# 61714)
This is a biotinylated form of the bovine grhelin peptide. The octanoyl modification
at Ser3 (n-octanoyl Ghrelin) is the major active form of ghrelin. Ghrelin is a
peptide hormone produced by the stomach in mammals, but also detectable in many
other tissues. Endogenous Ghrelin participates in the regulation of food intake,
body weight, energy homeostasis, it is an endogenous ligand for the growth hormone
secretagogue receptor (GHS-R) and is involved in the release of growth hormone from
the anterior pituitary.
Sequence: GS-S(n-octanoylated)-FLSPEHQKLQRKEAKKPSGRLKPR
Sequence (3-Letter):
H-Gly-Ser-Ser(n-octanoylated)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Leu-Gln-Arg-Lys-Glu-Ala-Lys-Lys-Pro-Ser-Gly-Arg-Leu-Lys-Pro-Arg-OH
Reference(s): ThidarMyint, H. et al. J. Endocrinol. 189, 655 (2006); Gauna, C. et
al. J. Clin. Endo. Metab. 90, 1055 (2005); Currie, P. et al. Am. J. Physiol. Regul.
Integr. Comp. Physiol. 289, R353 (2005); Arvat, E. et al. J. Clin. Endo. Metab 86,
1169 (2001).

Peptides/Protein Phosphorylation Related Peptides
(pS8, pS13) Eucariotic Translation Initiation Factor 2B, eIF2B (Cat# 61739)
This is an eukaryotic protein synthesis initiation factor 2B (elF2B), the double
phosphorylated amidated peptide. Dephosphorylation of this peptide by insulin
signaling and glycogen synthase kinase 3 (GSK3) inhibition leads to its activation.
The references below correspond to the single phosphorylated peptide.
Sequence: RRAAEELDpSRAGpSPQL
Sequence (3-Letter):
H-Arg-Arg-Ala-Ala-Glu-Glu-Leu-Asp-pSer-Arg-Ala-Gly-pSer-Pro-Gln-Leu-OH
Reference(s): Frame, S. et al. Mol. Cell. 7, 1321 (2001); Oreña, S. et al. J. Biol.
Chem. 275, 15765 (2000); Kang Ho Kim, et al. J. Biol. Chem. 279, 51999 (2004);
Niloulina, S. et al. Diabetes 51, 2190 (2002); Brady, M. et al. J. Biol. Chem. 273,
14063 (1998).

Gycogen Synthase-derived peptide, phosphorylated, TAMRA-labeled (Cat# 61725)
A TAMRA-labeled phosphorylated Glycogen synthese derived peptide (Ab/Em

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